Structure-activity relationship (SAR) analysis indicates that (i) the configuration of the chiral center in 1 (JIMB01) is not indispensable for the activity, (ii) the phenyl ring is essential, and (iii) a substitution at the 6-position of the phenyl ring with a halogen enhances the activity. Among the analogues, 11e and 14b bearing 6-fluoro substitution showed potent activities against nine human tumor cell lines, including CEM (leukemia), Daudi (lymphoma), MCF-7 (breast cancer), Bel-7402 (hepatoma), DU-145 (prostate cancer),

PC-3 (prostate cancer), DND-1A(melanoma), LOVO (colon cancer), and MIA Paca (pancreatic cancer) with IC(50) values between 0.01 and 0.30 mu M. 14b inhibited human hepatocarcinoma by 86% in volume in nude mice. The mechanism of 14b is to inhibit microtubule see more assembly, followed by the M-phase arrest, bcl-2 inactivation, and then apoptosis. We consider 14b promising for further anticancer investigation.”
“The roles of DNA repair by apurinic/apyrimidinic (AP) endonucleases alone, and together with DNA protection by alpha/beta-type small acid-soluble spore proteins (SASP), in Bacillus subtilis spore resistance

to different types of radiation have been studied. Spores lacking both AP endonucleases (Nfo and ExoA) and major SASP were significantly more sensitive to 254-nm UV-C, environmental find more UV (>280 nm), X-ray exposure, and high-energy charged (HZE)-particle bombardment and had elevated mutation frequencies compared to those of wild-type spores and spores lacking only one or both AP endonucleases or major SASP. These findings further implicate AP endonucleases and alpha/beta-type SASP in repair

and protection, respectively, of spore DNA against effects of UV and ionizing radiation.”
“Objective This study examined factors underlying racial differences in pain and function among patients with hip and/or knee osteoarthritis (OA)\n\nMethods Participants selleck kinase inhibitor were n = 491 African Americans and Caucasians enrolled in a clinical trial of telephone-based OA self-management Arthritis Impact Measurement Scales-2 (AIMS2) pain and function subscales were obtained at baseline Potential explanatory variables included arthritis self-efficacy, AIMS2 affect subscale, problem- and emotion-focused pain coping, demographic characteristics, body mass index, self-reported health, joint(s) with OA, symptom duration, pain medication use, current exercise, and AIMS2 pain subscale (in models of function) Variables associated with both race and pain or function, and which reduced the association of race with pain or function by >= 10%, were included in final multivariable models.\n\nResults In simple linear regression models, African Americans had worse scores than Caucasians on AIMS2 pain (B = 0 65, P = 0 001) and function (B = 0.59, P < 0.

27 (0.24-0.30) versus 0.40 (0.35-0.44) (p smaller than 0.001). Conservative oxygen therapy decreased the median total amount of oxygen delivered during mechanical ventilation by about two thirds (15,580 L [8,263-29,351 L] vs 5,122 L [1,837-10,499 L]; p smaller than 0.001). The evolution of the Pao(2)/Fio(2) ratio was similar LY3039478 Stem Cells & Wnt inhibitor during the two periods, and there were no difference in any other biochemical or clinical outcomes. Conclusions: Conservative oxygen therapy in mechanically ventilated ICU patients was feasible and free of adverse biochemical, physiological, or clinical outcomes while allowing a marked

decrease in excess oxygen exposure. Our study supports the safety and feasibility of future pilot randomized controlled trials of conventional compared with conservative oxygen therapy.”
“The red cusk-eel (Genypterus

chilensis) is an endemic fish species distributed along the coasts of the Eastern South Pacific. Biological studies on this fish are scarce, and genomic information for G. chilensis is practically nonexistent Thus, transcriptome information for this species is an essential resource that will greatly enrich molecular information and benefit future studies of red cusk-eel biology. In this work, we obtained transcriptome information of G. chilensis using the Illumina platform. The RNA sequencing generated 66,307,362 and 59,925,554 paired-end Apoptosis inhibitor reads from skeletal muscle and liver tissues, respectively.

De novo assembly using the CLC Genomic Workbench version 7.0.3 produced 48,480 contigs and created a reference transcriptome with a N50 of 846 bp and average read coverage of 28.3x. By sequence similarity search for known proteins, a total of 21,272 (43.9%) contigs were annotated for their function. Out of these annotated contigs, 335% GO annotation results for biological processes, 32.6% GO annotation results for cellular components and 34.5% GO annotation results for molecular functions. This dataset represents the first transcriptomic resource for the red cusk-eel and for a member of the Ophidiimorpharia taxon. (C) 2014 Elsevier B.V. All rights reserved.”
“In CRT0066101 nmr this work four cationic additives were used to improve the surface activity of lung surfactants, particularly in the presence of bovine serum that was used as a model surfactant inhibitor. Two of those additives were chitosan in its soluble hydrochloride form with average molecular weights of 113 kDa and 213 kDa. The other two additives were cationic peptides, polylysine 50kDa and polymyxin B. These additives were added to bovine lipid extract surfactant (BLES) and the optimal additive-surfactant ratio was determined based on the minimum surface tension upon dynamic compression, carried out in a constrained sessile drop (CSD) device in the presence of 50 mu l/ml serum. At the optimal ratio all the BLES-additive mixtures were able to achieve desirable minimum surface tensions.

The aims of this study

were to investigate the safety and efficacy of percutaneous coronary intervention for “true” CTO, defined by Thrombolysis In Myocardial Infarction (TIMI) flow grade 0 and duration >= 3 months, and to compare the outcome of successful versus failed procedures. A cohort of 172 consecutive patients with de novo CTOs of native vessels confirmed by angiographic review in which percutaneous coronary interventions were attempted was studied. End points included angiographic success, in-hospital complications, and long-term major adverse cardiac events. Technical success was obtained in 73.8% of CTO lesions (127 of 172). No deaths or nonfatal Q-wave myocardial infarctions occurred in the hospital. Repeat percutaneous coronary interventions in the hospital were required Selleck AZD8055 in 1.6% of patients (2 of 127) in whom the CTOs were initially opened. Perforation during the initial failed attempts occurred in 6.7% of patients (3 of 45). One patient required operative

repair. After an average follow-up period of 2 years, patients with successful procedures experienced similar incidences of cardiac death and nonfatal Q-wave myocardial infarctions as did patients with failed procedures (5.3% and 4.9%, respectively, p = 0.3). Patients with successfully opened arteries required target vessel revascularization more frequently, but this did not reach statistical significance (18.8% vs 0%, p = 0.06). In conclusion, attempts to open CTOs with the devices learn more available at the time of this registry were accompanied by a significant risk for perforation. Furthermore, successful recanalization did not translate into a reduction in 2-year mortality or nonfatal Q-wave myocardial infarctions compared with patients with failed procedures. (C) 2008 Elsevier Inc. All rights reserved. (Am J Cardiol 2008;102:1175-1181)”
“Schizophrenia has been considered a devastating clinical syndromerather than a single disease. Nevertheless, the mechanisms behind the onset of schizophrenia

have been only partially elucidated. Several studies Selleck JPH203 propose that levels of trace elements are abnormal in schizophrenia; however, conflicting data generated from different biological sources prevent conclusions being drawn. In this work, we used synchrotron radiation X-ray microfluorescence spectroscopy to compare trace element levels in neural progenitor cells (NPCs) derived from two clones of induced pluripotent stem cell lines of a clozapine-resistant schizophrenic patient and two controls. Our data reveal the presence of elevated levels of potassium and zinc in schizophrenic NPCs. Neural cells treated with valproate, an adjunctive medication for schizophrenia, brought potassium and zinc content back to control levels.

The gender groups did not differ in absolute measures of colour or in the rate at which it deteriorated on display. However, the rate of colour deterioration was more

rapid than other meats such as beef, as has been demonstrated elsewhere. The average ultimate pH and water-holding capacity were similar for the two groups. Venison from hinds contained click here more coenzyme Q(10), taurine, anserine, carnosine, and vitamin E. Group differences in fatty acid composition of intramuscular fat appeared to be mainly due to levels of fatness, which was greater for the hind group. (C) 2010 The American Meat Science Association. Published by Elsevier Ltd. All rights reserved.”
“Epidemiologic studies have found that obesity is associated with malignant grade and mortality in prostate cancer. this website Several adipokines have been implicated as putative mediating factors between obesity and prostate cancer. Fatty acid binding protein 4 (FABP4), a member

of the cytoplasmic fatty acid binding protein multigene family, was recently identified as a novel adipokine. Although FABP4 is released from adipocytes and mean circulating concentrations of FABP4 are linked with obesity, effects of exogenous FABP4 on prostate cancer progression are unclear. In this study, we examined the effects of exogenous FABP4 on human NSC23766 cell line prostate cancer cell progression. FABP4 treatment promoted serum-induced prostate cancer cell invasion in vitro. Furthermore, oleic acid promoted prostate cancer cell invasion only if FABP4 was present in the medium. These promoting effects were

reduced by FABP4 inhibitor, which inhibits FABP4 binding to fatty acids. Immunostaining for FABP4 showed that exogenous FABP4 was taken up into DU145 cells in three-dimensional culture. In mice, treatment with FABP4 inhibitor reduced the subcutaneous growth and lung metastasis of prostate cancer cells. Immunohistochemical analysis showed that the number of apoptotic cells, positive for cleaved caspase-3 and cleaved PARP, was increased in subcutaneous tumors of FABP4 inhibitor-treated mice, as compared with control mice. These results suggest that exogenous FABP4 might promote human prostate cancer cell progression by binding with fatty acids. Additionally, exogenous FABP4 activated the PI3K/Akt pathway, independently of binding to fatty acids. Thus, FABP4 might be a key molecule to understand the mechanisms underlying the obesity-prostate cancer progression link.”
“Background: Despite progress in identifying genes associated with breast cancer, many more risk loci exist. Genome-wide association analyses in genetically-homogeneous populations, such as that of Sardinia (Italy), could represent an additional approach to detect low penetrance alleles.

Visually significant, potentially life-threatening, and even treatable conditions were detected serendipitously during routine ROP screening

that may be missed or detected late otherwise. This pilot data may be used to advocate for a possible universal infant eye screening program using digital imaging.”
“The ability to control the differentiation of stem cells into specific neuronal types has a tremendous potential for the treatment of neurodegenerative diseases. Nutlin-3a solubility dmso In vitro neuronal differentiation can be guided by the interplay of biochemical and biophysical cues. Different strategies to increase the differentiation yield have been proposed, focusing everything on substrate topography, or, alternatively on substrate stiffness. Both strategies demonstrated an improvement of the cellular response. However it was often impossible to separate the topographical and the mechanical contributions. Here we investigate the role of the mechanical properties

of nanostructured substrates, aiming at understanding the ultimate parameters which govern the stem cell differentiation. To this purpose a set of different substrates with controlled stiffness and with or without nanopatterning are used for stem cell differentiation. Our results show that the neuronal differentiation yield depends mainly on the substrate Ion Channel Ligand Library clinical trial mechanical properties while the Veliparib order geometry plays a minor role. In particular nanostructured and flat polydimethylsiloxane (PDMS) substrates with comparable stiffness show the same neuronal yield. The improvement in the differentiation yield obtained through surface nanopatterning in the submicrometer scale could be explained as a consequence of a substrate softening effect. Finally we investigate by single cell force spectroscopy the neuronal precursor adhesion on the substrate immediately after seeding, as a possible critical

step governing the neuronal differentiation efficiency. We observed that neuronal precursor adhesion depends on substrate stiffness but not on surface structure, and in particular it is higher on softer substrates. Our results suggest that cell-substrate adhesion forces and mechanical response are the key parameters to be considered for substrate design in neuronal regenerative medicine. Biotechnol. Bioeng. 2013; 110: 2301-2310. (c) 2013 Wiley Periodicals, Inc.”
“A pleiotropic hormone, leptin, secreted into saliva by the acinar cells of salivary glands is an important mediator of the processes of oral mucosal defense. Here, we report on the role of epidermal growth factor receptor (EGFR) transactivation in the signaling events that mediate leptin protection of sublingual salivary gland acinar cells against ethanol cytotoxicity.

These results support the need for specific training in multi-turn reactive agility tasks.”
“Human immunodeficiency

virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported that ethanol and water extracts of Brasenia schreberi (Junsai) inhibited the DNA polymerase activity of HIV-1 RT [Hisayoshi et al. (2014) J Biol Macromol 14:59-65]. In this study, we screened 43 edible plants and found that ethanol and water extracts of Brasenia schreberi and water extract of Petasites japonicus strongly inhibit not only the activity of DNA polymerase to incorporate dTTP into poly(rA)-p(dT)(15) but also the activity of RNase H to hydrolyze the RNA strand of learn more an RNA/DNA hybrid. In addition, these three extracts inhibit HIV-1 replication in human cells, with EC50 values of 1-2 A mu g/ml. These results suggest that Brasenia schreberi and Petasites japonicus contain substances that block HIV-1 replication by inhibiting the DNA polymerase activity and/or RNase H activity of HIV-1 RT.”
“Chronic GVHD is a significant complication

following allogeneic click here hematopoietic stem cell transplantation; however, the clinical characteristics of chronic GVHD following cord blood transplantation (CBT) in adults have not been well described. Between March 2001 and November 2005, a total of 77 patients underwent CBT at eight transplantation centers of the Nagoya Blood and Marrow Transplantation Group. Of 77 patients, 29 survived without graft failure or progression

of underlying diseases for at least 100 days after transplantation. The median age of the 29 patients was 42 years (range, 18-67 years). Seven patients developed chronic GVHD (extensive, n = 4; limited, n = 3) disease. The cumulative incidence of chronic GVHD 1 year after day 100 was 24% (95% confidence interval (CI), 11-41%), and the organs involved were the skin (n = 6), oral cavity (n = 4), liver (n = 1) and gastrointestinal tract (n = 1). In three patients, chronic GVHD was resolved with supportive care. The remaining four were successfully treated with additional immunosuppressive therapy. Event-free survival rates Selleck PLX3397 of the 29 patients with and without chronic GVHD 3 years after day 100 were 83 (95% CI, 27-97%) and 36% (95% CI, 17-56%), respectively (P = 0.047). These results suggest that chronic GVHD following CBT is mild and has a graft-versus-malignancy effect.”
“Introduction Bacterial infection of endovascular stent grafts is a serious condition, regularly leading to graft replacement by open bypass surgery.\n\nCase Report We describe the case of a staphylococcal infection of a 150-mm covered stent graft (Gore Viabahn), placed in the superficial femoral artery.

5 years of data collected at Mbeli Bai in northern

Congo. Access to mates and offspring survival were both major sources of variance in male reproductive success. Males with larger harems had lower offspring mortality with no apparent reduction in female fertility or observed tenure length, so the size of harems did not seem to be limited by female feeding competition or by the risk of takeovers and infanticide by outsider males. The lower mortality in larger harems may reflect improved vigilance against predators, and females may cluster around males that enhance offspring survival. Thus, this study illustrates how a detailed analysis of the components of male Fer-1 reproductive success can shed light on the interrelated social and ecological aspects that affect it.”
“A novel tertiary amine catalyst (TAC) and trithiocarbonate (TTC) synergistic photo-induced controlled radical polymerization of methacrylates in the absence of conventional photo-initiators, metal-catalysts, MLN2238 Proteases inhibitor or dye sensitizers, has been realized under mild UV irradiation (lambda(max) approximate to 365 nm), yielding polymethacrylates with low molecular weight distributions and excellent end-group fidelity.”
“Loco-regional treatments play a key role in the management of hepatocellular carcinoma

(HCC). Image-guided tumor ablation is recommended in patients with early-stage HCC when surgical options are precluded. Radiofrequency ablation has shown superior anticancer effects and greater survival benefit with respect to the seminal percutaneous technique, ethanol injection, in meta-analyses of randomized controlled trials, and is currently established as the standard method for

local tumor treatment. Novel thermal and nonthermal techniques for tumor ablation including microwave ablation, selleck screening library irreversible electroporation, and light-activated drug therapy seem to have potential to overcome the limitations of radiofrequency ablation and warrant further clinical investigation. Transcatheter arterial chemoembolization (TACE) is the standard of care for patients with asymptomatic, noninvasive multinodular tumors at the intermediate stage. The recent introduction of embolic microspheres that have the ability to release the drug in a controlled and sustained fashion has been shown to significantly increase safety and efficacy of TACE with respect to conventional, lipiodol-based regimens. The available data for radioembolization with yttrium-90 suggests that this is a potential new option for patients with HCC, which should be investigated in the setting of randomized controlled trials. Despite the advances and refinements in loco-regional approaches, the long-term survival outcomes of patients managed with interventional techniques are not fully satisfactory, mainly because of the high rates of tumor recurrence.

05; p = 0.84), log(ANC) nadir (beta = -0.03; 95% CI, -0.10 to 0.04; p = 0.40), hemoglobin

nadir (beta = -0.09; 95% CI, -0.31 to 0.14; p = 0.452), or platelet nadir (beta = -3.47; 95% CI, -10.44 to 3.50; p = 0.339).\n\nConclusions: Irradiation of BM subregions with higher F-18-FDG-PET activity was associated with hematologic toxicity, supporting the hypothesis that reducing dose to BMACT subregions could mitigate hematologic toxicity. Future investigation should seek to confirm these findings and to identify optimal SUV thresholds to define BMACT. (C) 2012 Elsevier Inc.”
“Purpose: To determine whether optical imaging can be used for in vivo therapy response monitoring as an alternative to radionuclide techniques. For this, we evaluated the known Her2 response to 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG) Belnacasan Apoptosis inhibitor treatment, an Hsp90 inhibitor.\n\nExperimental Design: After in vitro 17-DMAG treatment response evaluation of MCF7 parental cells and 2 HER2-transfected

clones (clone A medium, BI-D1870 in vitro B high Her2 expression), we established human breast cancer xenografts in nude mice (only parental and clone B) for in vivo evaluation. Mice received 120 mg/kg of 17-DMAG in 4 doses at 12-hour intervals intraperitonially (n = 14) or PBS as carrier control (n = 9). Optical images were obtained both pretreatment (day 0) and posttreatment (day 3, 6, and 9), always 5 hours postinjection of 500 pmol of anti-Her2 Affibody-AlexaFluor680 via tail vein (with preinjection background subtraction). Days 3 and 9 in vivo optical imaging signal was further correlated with ex vivo Her2 levels by Western blot after sacrifice.\n\nResults: Her2 expression decreased with 17-DMAG dose in vitro. In vivo optical imaging signal was reduced by 22.5% in clone B (P = 0.003) and by 9% in MCF7 parental tumors (P = 0.23) 3 days after 17-DMAG treatment; optical imaging signal recovered in both tumor types at

days 6 to 9. In the carrier group, no signal reduction was observed. Pearson correlation of in vivo optical imaging FRAX597 manufacturer signal with ex vivo Her2 levels ranged from 0.73 to 0.89.\n\nConclusions: Optical imaging with an affibody can be used to noninvasively monitor changes in Her2 expression in vivo as a response to treatment with an Hsp90 inhibitor, with results similar to response measurements in positron emission tomography imaging studies. Clin Cancer Res; 18(4); 1073-81. (C)2012 AACR.”
“Introduction: Botulinum neurotoxin (BoNT) is probably the most potent biological toxin that can affect humans. Since its discovery by Justinus Kerner, BoNT has seen use in a wide range of cosmetic and non-cosmetic conditions such as cervical dystonia, cerebral palsy, migraines and hyperhidrosis. We tried to trace its history from its inception to its recent urological applications. Materials and Methods: Historical articles about botulinum toxin were reviewed and a Medline search was performed for its urological utility.

Although the degree of spinal cord histopathology and clinical severity was separated

from the PLP:139151-specific TH1/TH17 cell and antibody response, it was linked to the number of infiltrating macrophages and activated microglia. Cl-amidine chemical structure In particular, there was a correlation between their secretion product interleukin-1 beta and the degree of axonal loss. Although CD4+ T cells seem to be mainly involved in disease initiation, we suggest that it is the downstream activation of the innate immune response that defines the magnitude of the disease outcome. (C) 2012 Wiley Periodicals, Inc.”
“BACKGROUND: Light-to-moderate alcohol consumption is known to reduce the risk of coronary artery disease.\n\nOBJECTIVES: The purpose of this study was to investigate relationships of alcohol intake with atherogenic indices, such as the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C ratio) and the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio), in women.\n\nMETHODS: Subjects (14,067 women, 20-45 years) were divided by alcohol intake

into three groups of nondrinkers, occasional drinkers, and regular drinkers, and each drinker group was further divided into lower- (<22 g ethanol/drinking day) and greater- (>= 22 g ethanol/drinking day) quantity drinkers. Atherogenic indices were compared among the alcohol groups.\n\nRESULTS: Odds ratio (OR) for high LDL-C/HDL-C ratio or high TG/HDL-C ratio calculated after adjustment for age, body mass index, smoking, and habitual exercise GDC-0068 mw was significantly lower (P < .05) than a reference level

of 1.00 in regular or occasional lower- and higher quantity drinkers vs. nondrinkers (OR for high LDL-C/HDL-C ratio, 0.28 (95% confidence interval [95% CI], 0.18-0.44) in regular lower-quantity drinkers, 0.18 (95% CI, 0.12-0.28) in regular higher quantity drinkers, 0.71 (95% CI, 0.61-0.83) in occasional lower-quantity drinkers, and 0.53 (95% CI, 0.44-0.64) in occasional higher quantity drinkers; OR for high TG/HDL-C ratio, 0.52 (95% CI, 0.32-0.85) in regular lower-quantity drinkers, 0.67 (95% CI, 0.47-0.96) in regular higher-quantity VS-4718 drinkers, 0.61 (95% CI, 0.50-0.76) in occasional lower-quantity drinkers, and 0.63 (95% CI, 0.50-0.79) in occasional higher-quantity drinkers. Both LDL-C/HDL-C ratio and log-transformed TG/HDL-C ratio were significantly greater in smokers than in nonsmokers. Both in smokers and nonsmokers, LDL-C/HDL-C ratio and log-transformed TG/HDL-C ratio were significantly lower in regular lower- and higher-quantity drinkers than in nondrinkers. In nonsmokers, LDL-C/HDL-C ratio and log-transformed TG/HDL-C ratio tended to be lower and greater, respectively, in regular greater-quantity drinkers than in regular lower-quantity drinkers.

Moreover, because the flooding regime of Amazonian rivers is strongly related to large-scale climatic phenomena, there might be a perilous connection between climate change and the future prospects for the species. Our experience reveals that the success of research and conservation of

wild Amazonian manatees depends on close working relationships with local inhabitants.”
“Although indices of aortic augmentation derived from radial applanation tonometry are independently associated with adverse cardiovascular BKM120 clinical trial effects, whether these relationships are influenced by gender is uncertain. We compared the brachial blood pressure-independent contribution of augmentation index (AIx) to variations in left ventricular mass index (LVMI) in a community sample of 808 participants, 283 of whom were men.

Aortic haemodynamics were determined using radial applanation tonometry and SphygmoCor software and LVMI from echocardiography. In men, both AIx derived from aortic augmentation pressure/central aortic pulse pressure (AP/PPc; partial r = 0.17, beta-coefficient +/- s.e.m. = 0.55 +/- 0.20, P smaller than 0.01) and AIx derived from the second peak/first peak (P-2/P-1) of the Selleck HIF inhibitor aortic pulse wave (partial r = 0.21, beta-coefficient +/- s.e.m. = 0.42 +/- 0.12, P smaller than 0.0005) were associated with LVM indexed to body surface area (LVMI-BSA). In contrast, in women, neither AIx derived from AP/PPc (partial r = – 0.08, beta-coefficient +/- s.e.m. = – 0.20 +/- 0.11, P = 0.08) nor AIx derived from P-2/P-1 (partial r = -0.06, beta-coefficient +/- s.e.m. = -0.07+/-0.05, P = 0.17) were associated with LVMI-BSA. Both the strength of the correlations (P smaller than 0.001 and P smaller than 0.0005 with z-statistics) and the slope

of the AIx-LVMI relationships (P = 0.001 and P smaller than 0.0005) were greater in men as compared with women. The lack of relationship between Caspase inhibitor AIx and LVMI was noted in both premenopausal (n = 285; AP/PPc vs. LVMI-BSA, partial r = 0.01, P = 0.95, P-2/P-1 vs. LVMI-BSA, partial r = 0.02, P = 0.77), and postmenopausal (n = 240; AP/PPc vs. LVMI-BSA, partial r = -0.06, P = 0.37, P-2/P-1 vs. LVMI-BSA, partial r = -0.03, P = 0.64) women. Similar differences were noted in the relationships between AIx and LVM indexed to height(2.7) in men and women. In conclusion, radial applanation tonometry-derived AIx may account for less of the variation in end-organ changes in women as compared with men.”
“Sequence analysis of segment 2 (seg-2) of three Indian bluetongue virus (BTV) isolates, Dehradun, Rahuri and Bangalore revealed 99% nucleotide identity amongst them and 96% with the reference BTV 23. Phylogenetic analysis grouped the isolates in ‘nucleotype D’. The deduced amino acid (aa) sequence of the Bangalore isolate showed a high variability in a few places compared to other isolates. B-cell epitope analyses predicted an epitope that is present exclusively in the Bangalore isolate.