Conclusions In conclusion, by the addition of CC49, we generated a specific QD molecule that not only has the potential to bind tumor cell in vitro but also could be used in a long-term therapeutic regimen to possibly alter individual cancer treatment. Further preclinical studies utilizing our CC49-QDs fusion construct, addressing the short-term and long-term capabilities, will be performed to develop regimens for improved Selleck Foretinib gastric cancer treatment. Acknowledgements This study was supported by the National Nature Science Foundation of China (no. 20874015) and the Science and Technology Commission Nano Special Fund of the Selumetinib datasheet Shanghai Municipality (no. 1052nm03802). References 1. Gómez-Martin C, Sánchez A, Irigoyen
A, Llorente B, Pérez B, Serrano R, Safont MJ, Falcó E, Lacasta A, Reboredo M, Aparicio J, Dueñas R, Muñoz ML, Regueiro P, Sanchez-Viñes E, López RL: Incidence of hand-foot syndrome with capecitabine in combination with chemotherapy
as first-line treatment in patients with advanced and/or metastatic gastric cancer suitable for treatment with a fluoropyrimidine-based regimen. Clin Transl Oncol 2012,14(9):689–697.CrossRef 2. Pericleous P, Gazouli M, Lyberopoulou A, Rizos S, Nikiteas N, Efstathopoulos EP: Quantum dots hold promise for early cancer imaging and detection. Int J Cancer 2012, 131:519–528.CrossRef 3. Chen C, Peng J, Sun SR, Peng CW, Li Y, Pang DW: Tapping the potential of quantum dots for personalized oncology: current status and future perspectives. Nanomedicine (Lond) 2012,7(3):411–428.CrossRef 4. Xue see more B, Deng DW, Cao J, Liu F, Li X, Akers W, Achilefu S, Gu YQ: Synthesis of NAC capped near infrared-emitting CdTeS alloyed quantum dots and application for in vivo early tumor imaging. Aprepitant Dalton Trans 2012,41(16):4935–4947.CrossRef 5. Yang K, Cao YA, Shi C, Li ZG, Zhang FJ, Yang J, Zhao C: Quantum dot-based visual in vivo imaging for oral squamous
cell carcinoma in mice. Oral Oncol 2010,46(12):864–868.CrossRef 6. Frangioni JV, Kim SW, Ohnishi S, Kim S, Bawendi MG: Sentinel lymph node mapping with type-II quantum dots. Methods Mol Biol 2007, 374:147–159.CrossRef 7. van Vlerken LE, Amiji MM: Multi-functional polymeric nanoparticles for tumour-targeted drug delivery. Expert Opin Drug Deliv 2006,3(2):205–216.CrossRef 8. Ballou B, Ernst LA, Andreko S, Harper T, Fitzpatrick JA, Waggoner AS, Bruchez MP: Sentinel lymph node imaging using quantum dots in mouse tumor models. Bioconjug Chem 2007,18(2):389–396.CrossRef 9. Gaponik N, Talapin DV, Rogach AL, Hoppe K, Shevchenko EV, Kornowski A, Eychmuller A, Weller H: Thiol-capping of CdTe nanocrystals: an alternative to organometallic synthetic routes. J Phys Chem B 2002, 106:7177–7185.CrossRef 10. Derfus AM, Chan WCW, Bhatia SN: Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004, 4:11–18.CrossRef 11. Gao X, Cui Y, Levenson RM, Chung LW, Nie S: In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004, 22:969–976.CrossRef 12.