There is a division of the complete set of critical points into layers, the minimum energy surface forming the lowest.”
“Objectives: The exact pathogenesis of lumbar pain and radiculopathy is often poorly understood. Although nerve root entrapment resulting in mechanical pressure has been the most widely held concept to explain radiculopathy and lumbar pain, much of the recent research work increasingly supports an inflammatory reaction occurring in
the lumbar intervertebral disc tissue. In this study, we aimed to show the role of Myeloperoxidase as an inflammatory marker and the correlation of inflammation with lumbar radiculopathy.\n\nMethods: We evaluated 15 patients and 15 healthy controls of drug discovery a similar age and sex distribution. Myeloperoxidase activities in polymorphonuclear leukocytes were measured spectrophotometrically by the method of Lowry’s.\n\nResults: The mean Myeloperoxidase level was 440 U/mg protein in the patient group and 142 U/mg protein in the control group. The Myeloperoxidase levels of patients in the lumbar radiculopathy SC79 in vitro group were significantly higher than in the control group (p<0.001).\n\nConclusion: In this preliminary study, we had found increased Myeloperoxidase
level in the lumbar disc patients with radiculopathy. The significantly high level of Myeloperoxidase might indicate a systemic inflammatory response to impingement of the nerve root caused by lumbar disc herniation. This led us to think that Myeloperoxidase might play a role in the activity status of the disease.”
Hypertension is a common cardiovascular disease, affecting adults worldwide and it accounts for up to 30% of all deaths. The need for better control of arterial hypertension justifies observational studies designed to better understand the real-life management of hypertensive patients. The ASTRAL study was primarily designed to evaluate the percentage of hypertensive patients achieving blood pressure goals after eight weeks of treatment with a fixed-dose combination of ramipril/hydrochlorothiazide (HCTZ).\n\nMethods: The study was a multi-centre, non-comparative, open-label, observational study conducted in 36 centres in five sub-Saharan African countries, namely Cameroon, Congo Brazzaville, Democratic Republic of Congo (DRC), Madagascar and Nigeria. Four hundred and forty-nine R406 research buy men and women 18 years of age or older with hypertension not controlled by an ACE inhibitor, a diuretic or any other mono-therapy or anti-hypertensive combination not containing a diuretic in a fixed dose were considered eligible for inclusion in this eight-week study. The study consisted of three visits, visit one (V1) at baseline, visit two (V2) after four weeks and visit three (V3) after eight weeks.\n\nResults: The mean age of the patients was 54.7 +/- 11.7 years (20-90 years) and most were categorised by the WHO criteria as either overweight or obese (71.6%).