\n\nResults: Of 1180 eligible
women, 1087 were approached and 1044 (88%) consented to participate. Among the 987 women for whom a questionnaire and a definitive diagnostic assay were available, the prevalence of chlamydia was 3.2% (95% Cl 1.8 to 5.9). In a multiple logistic regression model, more than one sexual partner in the past year (AOR 11.5; 95% Cl 7.1 to 18.5) was associated with chlamydia infection. The use of any antibiotic within 3 months (AOR 0.2; 95% Cl 0.1 to 0.6) was associated with a decreased risk of infection. Screening restricted to women who reported more than one sexual partner in the past year would have detected 44% of infections in women aged 16-25 years and would have required only 7% of women to be screened. The addition of those women aged 20 years and under would have required 27% of women to be screened and detection of 72% https://www.selleckchem.com/products/gdc-0068.html of infections.\n\nConclusions: Selective chlamydia screening of pregnant women based on risk factors can improve the yield from screening. However, the potential harm of missed infections among excluded women would need to be considered.”
“Background: Vascular calcifications ( VCs) contribute
to the massive mortality in hemodialysis ( HD) patients. We aimed to identify prevalence and risk factors for arterial medial calcifications ( AMCs) versus intimal calcifications ( AICs) in a single-center HD population.\n\nMethods: This cross-sectional study included 134 patients, mean age 56.9 +/- 9.7 years, on HD for 8.2 +/- 5.0 years.
VCs were scored based on plain radiographs and ultrasonography of the common carotid Small molecule library arteries.\n\nResults: Patients were categorized into groups I ( 13% without VC), II ( 10% with an AMC pattern), III ( 24% with an AIC pattern) and IV ( 53% with a mixed pattern). AIC and mixed patterns were associated with older age ( p=0.006 and p=0.004, respectively), and mixed pattern with longer dialysis vintage ( p=0.001). Pulse pressure was significantly higher in patients from group III than group IV, and intima-media thickness ( IMT) was higher in both groups with AIC. By multivariate analysis, risk factors for any VC were high serum Ca, phosphate, Ca x P product, low total protein, high body mass index ( BMI), systolic and diastolic blood pressure, IMT and history of smoking. Elevated GSK461364 calcium and/or phosphate predicted an AMC pattern, and high calcium, BMI and IMT an AIC pattern. Finally, high IMT, systolic blood pressure, BMI and older age were predictors of a mixed pattern.\n\nConclusion: We observed a very high prevalence of VC, mostly with a mixed AIC+AMC pattern. Apart from well-known risk factors, the data stress the importance of smoking, an under-recognized cause of AMC, and systolic blood pressure for AIC+AMC.”
“Female gender is an established risk factor for worse outcomes after cardiac surgery.