Perceived efficacy was rated as excellent or good by 62% of study subjects. The tested
compound was well tolerated; one nonserious adverse event was reported in the overall study population, and perceived tolerability was rated excellent or good by 99% of the subjects. In conclusion, dietary supplementation with the tested compound shows potential for counteracting cognitive impairment in subjects with mild cognitive impairment and warrants further investigation in adequately controlled, AZD9291 supplier longer-term studies.”
“Study Design. Translation, cross-cultural adaptation, and validation were performed on the Chinese version of the Oswestry Disability Index (ODI).
Objective. The objective of this study was to translate and adapt the ODI into simplified Chinese and to then validate its use in Chinese patients with low back pain.
Summary of Background Data. A traditional Chinese version of the ODI (TCODI) has been developed and used in Hong Kong. However, there is no simplified Chinese version of the ODI (SCODI).
Methods. Translation and cross-cultural adaptation of the latest version of the ODI (2.1a) were performed following instructions from the published international guidelines. The translation procedure included forward translation, back translation, and a discussion among experts. The prefinal version was tested in 40 outpatients with LBP. Then, 179 patients with LBP, including 140 outpatients and 39 inpatients, participated in the final test.
They finished the SCODI, the Short-Form 36, and the Visual Analog AC220 concentration Scale. Those 39 inpatients also finished a second ODI questionnaire this website within 24 hours. Last, the SCODI and TCODI were tested in another 25 inpatients for comparison.
Results. All of the patients in the prefinal test understood the simplified
Chinese version correctly. In the final test, Cronbach’s alpha for internal consistency was 0.93. A very high intraclass correlation coefficient was observed (ICC = 0.99) in the test-retest group. The SCODI showed a significant correlation with the 8 subscales of the Short-Form 36, especially in physical functioning (r = 0.78, P < 0.001). There was a moderate correlation between the ODI scores and the Visual Analog Scale (r = 0.69, P < 0.001). A significant difference in the mean score was demonstrated between the SCODI and the TCODI. Patients who participated in the comparison test all agreed that the SCODI was easier to understand than the TCODI.
Conclusion. The results showed that the translation and adaptation were successful. The SCODI has proven to be valid and reliable when used in the simplified Chinese speaking population.”
“Background Metastatic involvement of the penis is most commonly from a primary malignant genitourinary tumour. It is a rare phenomenon usually reflecting disseminated malignancy associated with a poor prognosis. Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease.