We found that compared PLX3397 to subjects with the CC or CT genotype, those with the TT genotype for an SNP at intron 2 (rs179851) were significantly overrepresented among the subjects with higher scores for osteophyte formation (P = 0.0001; odds ratio 2.12; 95% confidence interval 1.45-3.11, as determined by logistic regression
analysis) and disc space narrowing (P = 0.0057; odds ratio 1.83; 95% confidence interval 1.19-2.83). Consistent with the involvement of the HAPLN1 gene in cartilage metabolism, a variation in a specific HAPLN1 gene locus may be associated with spinal degeneration.”
“Background: In acute myocardial infarction (AMI), both tissue necrosis and edema are present and both might be implicated in the development of intraventricular dyssynchrony. AZD6094 inhibitor However, their relative contribution to transient dyssynchrony is not known. Cardiovascular magnetic resonance (CMR) can detect necrosis and edema with high spatial resolution and it can quantify dyssynchrony by tagging techniques.
Methods: Patients with a first AMI underwent percutaneous coronary interventions (PCI) of the infarct-related artery within 24 h of onset of chest pain. Within 5-7 days after the event and at 4 months, CMR was performed. The CMR protocol included the evaluation of intraventricular dyssynchrony by applying a novel 3D-tagging sequence
to the left ventricle (LV) yielding the CURE index (circumferential uniformity ratio estimate; 1 = complete synchrony). On T-2-weighted images, edema was measured as high-signal (>2 SD above EVP4593 remote tissue)
along the LV mid-myocardial circumference on 3 short-axis images (% of circumference corresponding to the area-at-risk). In analogy, on late-gadolinium enhancement (LGE) images, necrosis was quantified manually as percentage of LV mid-myocardial circumference on 3 short-axis images. Necrosis was also quantified on LGE images covering the entire LV (expressed as % LV mass). Finally, salvaged myocardium was calculated as the area-at-risk minus necrosis (expressed as % of LV circumference).
Results: After successful PCI (n = 22, 2 female, mean age: 57 +/- 12y), peak troponin T was 20 +/- 36ug/l and the LV ejection fraction on CMR was 41 +/- 8%. Necrosis mass was 30 +/- 10% and CURE was 0.91 +/- 0.05. Edema was measured as 58 +/- 14% of the LV circumference. In the acute phase, the extent of edema correlated with dyssynchrony (r(2) = -0.63, p < 0.01), while extent of necrosis showed borderline correlation (r(2) = -0.19, p = 0.05). PCI resulted in salvaged myocardium of 27 +/- 14%. LV dyssynchrony (=CURE) decreased at 4 months from 0.91 +/- 0.05 to 0.94 +/- 0.03 (p < 0.004, paired t-test). At 4 months, edema was absent and scar % LV slightly shrunk to 23.7 +/- 10.0% (p < 0.002 vs baseline).