There was also strong evidence that low in-treatment adherence with exercise (3 trials, 287 participants) was a barrier to longer term exercise adherence. There was conflicting

evidence that age and greater pain at baseline were barriers to treatment adherence. Limited evidence was found for a range of other http://www.selleckchem.com/products/i-bet-762.html variables with one good quality study supporting each of them. This systematic review summarised the results from 20 high quality studies and found strong evidence that low levels of physical activity at baseline or in previous weeks, low in-treatment adherence with exercise, low self-efficacy, depression, anxiety, helplessness, poor social support or activity, greater perceived number of barriers to exercise and increased pain levels during exercise are barriers to treatment adherence. There was conflicting evidence regarding age and pain at baseline. Many other variables had limited evidence of being barriers to adherence. The results

of this review are in line with others which have found that non-adherent individuals were likely to have lower Veliparib solubility dmso levels of prior activity, lower exercise self-efficacy, greater number of barriers and low levels of social support (Martin and Sinden, 2001 and Jackson et al., 2005). These reviews vary from our own in that

psychological variables such as anxiety, stress and helplessness did not emerge as predictive. In the review by Martin and Sinden SPTLC1 (2001) few studies investigated whether psychological variables predicted adherence of non-clinical populations of older adults to exercise intervention. In the review by Jackson et al. (2005) there was conflicting evidence for depression and anxiety in patients attending Cardiopulmonary Rehabilitation (CPR). One reason for this could be that these traits are more likely to be present in women, who are less likely to be referred to CPR. Therefore these symptoms may be less likely to emerge as predictors of non-adherence in CPR (Benz Scott et al., 2002). This review was conducted in accordance with guidelines from the Centre for Reviews & Dissemination (CRD, 2001), however the possibility of publication bias cannot be excluded (Altman, 1991). Unpublished studies and studies from lesser known databases or published in languages other than English may have been missed. Our review considered a range of musculoskeletal conditions and study populations.