The chromosome-4 break points in this translocation are clustered in a 70-kb region centromeric to the FGFR3 gene. We hypothesized that this translocation may impact the mutation rate at the G1138A site. We employed a semi-quantitative polymerase chain reaction-based assay to measure the frequency of this mutation in multiple myeloma cell lines carrying t (4; 14) translocation.
Analysis of these cell lines varied from no change to a 10-fold increase in the mutation frequency compared with normal controls. In general, there was an increase in the G1138A mutational frequency suggesting that chromosomal rearrangement can affect the stability of the CpG hotspots.”
“In situ x-ray diffraction spectra (25-1000 degrees C) have been measured as a function of temperature for proton-conducting Ba(Zr0.8-xCexY0.2)O-2.9 (x=0.0-0.4) ceramics in CO2 atmosphere. Atomic vibrations before Selleck BMS-777607 and after exposure AZD1208 mouse to CO2 were obtained by using the micro-Raman scattering (150-1600 cm(-1)). Ba(Zr0.8Y0.2)O-2.9 and Ba(Zr0.6Ce0.2Y0.2)O-2.9 reveal a promising thermal stability in CO2 without apparent decomposition up to 1000 degrees C. However, Ba(Zr0.5Ce0.3Y0.2)O-2.9 and Ba(Zr0.4Ce0.4Y0.2)O-2.9 exhibit thermally stable below 550 degrees C and then proceed an obvious chemical decomposition of BaCO3 and Zr0.8-xCexY0.2O2 above 550 degrees C, which were clearly evidenced by the Raman vibrations of 1057 and 466 cm(-1), respectively.
A first-order orthorhombic-hexagonal structure transition was confirmed in BaCO3 in the region of 810-850 degrees C upon heating. This study suggests that the Ba(Zr0.8-xCexY0.2)O-2.9 ceramics with x <= 0.2 are promising candidates for proton-conducting applications in CO2-containing environment.”
“Introduction: Postpartum depression (PPD) FG-4592 in vitro is one of the major psychological disorders worldwide that affects both mother and child. The aim of this study was to correlate the risk of PPD with obstetric and demographic variables in Saudi females.
Materials and methods: Data were collected by interviewing females 8-12 weeks postpartum. PPD symptoms were defined as present
when subjects had an Edinburgh Postnatal Depression Scale score of 10 or higher. Variables included in this study were age, education, occupation, parity, baby’s sex, pregnancy period, delivery type, hemoglobin level, anemia, and iron pills taken during pregnancy.
Results: Of the 352 postpartum females, the prevalence of PPD symptom risk was 117 (33.2%). Among the PPD symptomatic females, 66 (39.8%) had low hemoglobin levels, and 45 (40.5%) females were anemic during pregnancy (P <= 0.05). These results suggest that early postpartum anemia, indicated by low hemoglobin level, is a significant risk factor for PPD (adjusted odds ratio 1.70, 95% confidence interval 1.05-2.74; P=0.03). Other variables, including age, parity, education, occupation, and delivery type, were not significantly correlated (P=0.15-0.