Participants included 158 families (N Gamma-secretase inhibitor = 474) with a mother, a father, and a son or daughter aged 22 to 49 years. Actor-partner

interaction models revealed that parents and offspring who self-reported greater ambivalence showed poorer psychological well-being. Partner reports of ambivalence were associated with poorer physical health. When fathers reported greater ambivalence, offspring reported poorer physical health. When grown children reported greater ambivalence, mothers reported poorer physical health. Fathers and offspring who scored lower in neuroticism showed stronger associations between ambivalence and well-being. Findings suggest that parents or offspring may experience Daporinad mw greater ambivalence when the other party is in poorer health and that personality moderates associations between relationship qualities and well-being.”
“The accumulation of beta-amyloid (A beta) is the earliest event seen in the neocortex and hippocampus of Alzheimer’s disease (AD) patients. Transgenic mouse models of A beta deposition are excellent tools for validating pharmacological therapies for reducing A beta burden. Sensitive and rapid probes should be needed for detecting A beta

plaques ex vivo and in vivo in the transgenic mouse models. However, a thioflavin derivative, Pittsburgh Compound-B (PIB), which is a successful PET tracer for detecting A beta plaques in AD brains, does not visualize A beta plaques in APP and PS1/APP transgenic mice. Here, we report

that Hoechst 33342, a cell-permeable fluorescent probe for staining DNA and nuclei, also detects A beta plaques in APP Tg Mouse. These findings could allow us to rapidly detect A beta plaques in AD mouse models, and to develop improved compounds for detecting A beta plaques in vivo in mouse models. (C) 2008 Elsevier Ireland Ltd. All rights Selleck SCH772984 reserved.”
“In this study, we examined the relationship between within-person blood pressure and cognitive functioning. We conducted an analysis on 36 community-dwelling elderly individuals (age range = 60-87 years). Participants measured (heir blood pressure and completed cognitive tasks (i.e., the Rey Auditory Verbal Learning Task, the Letter Series test, and the Number Comparison test) twice a day over 60 consecutive days. We (observed a significant interaction between within-person change in blood pressure and average blood pressure for the Letter Series test. Individuals with high blood pressure tended to perform poorly, particularly on occasions when their blood pressure level was above their personal average. These results demonstrate that the relationship between blood pressure and cognition at the between-person level and the relationship within each individual should he further explored simultaneously.