One of the O-glycans was identified as hexuronic acid, whose presence had not been observed previously in the glycosylation patterns of T. reesei.”
“Purpose: Malignant ureteral obstruction often necessitates chronic urinary diversion and is Cyclopamine associated with high rates of failure with traditional ureteral stents. We evaluated the outcomes of a metallic stent

placed for malignant ureteral obstruction and determined the impact of risk factors previously associated with increased failure rates of traditional stents.

Materials and Methods: Patients undergoing placement of the metallic Resonance (R) stent for malignant ureteral obstruction at an academic referral center were identified retrospectively. Stent failure was defined

as unplanned stent exchange or nephrostomy tube placement for signs or symptoms of recurrent ureteral obstruction (recurrent hydroureteronephrosis or increasing creatinine). Predictors of time to stent failure were assessed using Cox regression.

Results: A total of 37 stents were placed in 25 patients with malignant ureteral obstruction. Of these stents 12 (35%) were identified to fail. Progressive hydroureteronephrosis and increasing creatinine were the most common signs of stent failure. Three failed stents had migrated distally and no stents required removal for recurrent infection. Patients with evidence of prostate cancer invading the ARS-1620 cell line bladder at stent placement were found to have a significantly increased risk of failure (HR 6.50, 95% CI 1.45-29.20, p = 0.015). Notably symptomatic subcapsular hematomas were identified

in 3 patients after metallic stent placement.

Conclusions: Failure rates with a metallic stent are similar to those historically observed with traditional polyurethane based stents in malignant ureteral obstruction. The invasion of prostate cancer in the bladder significantly increases the risk of failure. Patients should be counseled and observed for subcapsular hematoma formation with this device.”
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