Key Word(s): 1. Fundic gland polyps; 2. hyperplastic polyps;

3. adenomatous polyps; 4. colorectal neoplasia; Presenting Author: YOUNG JAE BYUN Additional Authors: DONG SOO HAN, YU HWA LEE, YOUNGOUK RO, SUN MIN KIM, TAE YEOB KIM, CHANG SOO EUN, KYO-SANG YOO, YONG CHEOL JEON, JOO HYUN SOHN Corresponding Author: DONG SOO HAN Affiliations: Hanyang University Guri Hospital Objective: Patients with functional constipation are often recommended to increase dietary fiber intake. Overactive bladder (OAB) may be associated with bowel symptoms. We examined the associations among functional constipation, dietary fiber intake, and OAB in Korean CAL 101 population cohort. Methods: This cohort study, using a reliable and valid questionnaire based on the Rome III criteria was performed in Yangpyeong city, Korean community on subjects aged ≥40 years between 2011 and 2012. Total, grain, vegetable, fruit and seaweed fiber intakes were estimated

from dietary questionnaires. OAB was defined through overactive bladder symptom score. The associations among functional constipation, dietary fiber intake, and OAB were assessed separately by age and gender. Results: A total of 1,173 patients were enrolled, with mean age of 62.4 ± 29.0, of which 63% was comprised of women. There were 134 (11.4%) patients with functional constipation. Total fiber intake was associated with a significantly lower prevalence of functional constipation in men, not in women. On the contrary, OAB was correlated with functional constipation in elderly women. Conclusion: Men who consumed high amount of fiber have a lower prevalence of functional constipation. PI3K inhibitor OAB is associated with functional constipation in elderly women. This population-based study suggests that the pathogenesis of functional constipation

Arachidonate 15-lipoxygenase may be different between men and women. Key Word(s): 1. Constipation; 2. Dietary fiber; 3. Overactive bladder; 4. Cohort study; Presenting Author: HUA YANG Additional Authors: BING-QING XIA, BO JIANG, YI-PENG YANG, HAO CHEN, BING-SHENG LI LI, AN-GAO XU, YUN-BO HUANG, XIN-YING WANG Corresponding Author: HUA YANG Affiliations: Nanfang Hospital, Southern Medical University; Huizhou Medical Institute Objective: The diagnostic value of stool DNA (sDNA) testing for colorectal neoplasms remains controversial. To compensate for the lack of large-scale unbiased population studies, we performed a meta-analysis to evaluate the diagnostic value of sDNA testing for multiple markers of colorectal cancer (CRC) and advanced adenoma. Methods: The Pubmed, Science Direct, Biosis Review, Cochrane Library, and Embase databases were systematically searched in January 2012 without time restriction. Meta-analysis was performed using a random-effects model using sensitivity, specificity, diagnostic odds ratio (DOR), summary receiver-operating characteristic (sROC) curves, area under the curve (AUC), and 95% confidence intervals (95% CIs) as effect measures.