J Gastrointest Surg 2006, 10:798–803.PubMedCrossRef 13. van Hooft JE, Bemelman WA, Oldenburg B, Marinelli AW, Holzik MF, Grubben MJ, Sprangers MA, Dijkgraaf MG, Fockens P, collaborative buy KPT-8602 Dutch TSA HDAC chemical structure Stent-in study group: Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial. Lancet Oncol 2011, 12:344–352.PubMedCrossRef 14. Zhang Y, Shi J, Shi B, Song CY, Xie WF, Chen YX: Self-expanding

metallic stent as a bridge to surgery versus emergency surgery for obstructive colorectal cancer: a meta-analysis. Surg Endosc 2012, 26:110–119.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contribution VC initiated the research project and collected all data. TB provided PXD101 order clinical data and reviewed the quality of data collection. PP provided community based follow-up data. SS managed the project, analyzed data and prepared the manuscript draft. All authors read and approved the final manuscript.”
“Background Hematoma

or rupture of the spleen is an uncommon finding in the absence of blunt abdominal trauma [1]. Splenic hemorrhage without trauma has been described in pathologic cases, such as infection, but remains exceeding rare in healthy individuals with a normal spleen. Cocaine-associated splenic pathology, ranging from infarction to hematoma, has been previously described in reports in the literature [1–3]. This report of a healthy

42-year old man is the first to describe splenic rupture as a cause for hemorrhage following use of intranasal cocaine. Although uncommon, atraumatic splenic rupture needs to be recognized because it is Tenofovir price potentially fatal. This case report with a brief review of the literature is intended to raise awareness of splenic bleeding as an etiology to be included in the differential diagnosis of acute abdominal pain and underlines the importance of a detailed social history. Presentation of case The patient is a 42-year-old man with no significant past medical history, aside from habitual cocaine use, who presented with excruciating left-sided abdominal pain after he consumed intranasal cocaine. The pain was constant, sharp, and nonradiating. Two days prior to presentation, he felt an acute onset of left upper quadrant pain immediately following a cough. The pain then became diffuse and more severe, prompting him to seek treatment in the emergency department (ED). He endorsed a similar left upper quadrant pain a few weeks prior, but that episode was less severe and resolved on its own. He denied any history of trauma, sick contacts, or recent travel. On arrival to the ED, the patient’s vital signs were as follows: temperature of 36.