Finally, several procedure-related factors such as stent dimensions [30], implantation of multiple stents [19] and [28], or an insufficient dilatation effect of CAS [19], [20] and [28] could be identified to promote Ku-0059436 datasheet ISR. Recurrent stenosis after CEA was first described by Stoney and String in 1976 [37] and turned out to be associated with a higher rate of periprocedural complications during a secondary operation [9]. Soon after CAS had received broader

acceptance as a potential alternative treatment option for patients with severe carotid artery stenosis, first reports about ISR were published in the late 1990s [38], [39] and [40]. Since then, the awareness for detecting an ISR has increased further and was more frequently considered in published case series. Within one of the most recent meta-analyses, a 180% increase in the risk of intermediate to long-term carotid restenosis was observed after CAS as compared to CEA. [41] Since CAS is currently widely used as a treatment alternative to CEA, it is necessary to contribute to the ongoing controversial discussion regarding the incidence,

buy PLX3397 clinical significance and appropriate therapeutic management of ISR in order to ameliorate long-term efficacy. With regard to the etiology of ISR, there may be some similar mechanisms to recurrent stenosis after coronary artery stenting. First of all, an endothelial injury which is caused e.g. by balloon inflation and stent placement, seems to

play a major role for the developing of ISR, both after CAS or coronary artery stenting. This damage could initiate a cascade of inflammational processes, which finally leads to a neointimal proliferation and a concentric vessel lumen reduction. Like Schillinger et al. [20] we were recently able to support the notion of an inflammatory cascade as a main cause for ISR by showing that elevated periprocedural inflammation markers are significantly correlated with the development of an ISR [30]. The initial injury of the endothelial layer caused by balloon inflation, guide-wire manipulation or stent placement might explain why additional procedural factors could be identified within our literature review to influence the occurrence of ISR: the use of multiple stents during CAS [19] and [28] or even wider and longer stent dimensions by their own [30] Masitinib (AB1010) could be identified to be associated with a higher incidence of ISR. Potential endothelial injuries by either an amplified sheer force of the stent, a more pronounced abrasion or higher inflation pressure during the procedure are some of the discussed issues accountable for restenosis. Despite the heterogeneity of the analysed studies, one of the most common findings was the time during which an ISR could be detected as it seems to develop most frequently within the first year after a CAS intervention [16], [18], [20], [21], [26], [29] and [30].