8 +/- 1.6 vs. -18.6 +/- 1.0, p < 0.001) and peak diastolic strain rate (83 +/- 26 vs. 114 +/- 16 s-1, p < 0.001) in SSc, which inversely correlated with diffuse myocardial fibrosis indices.
Conclusions: Cardiac involvement is common in SSc even in the absence of cardiac symptoms, and includes chronic myocardial inflammation as well as focal and diffuse myocardial fibrosis. Myocardial abnormalities detected on CMR were associated with impaired strain parameters, as well as disease activity and severity in SSc patients. CMR may be useful in future in the study of treatments aimed at preventing or reducing adverse
myocardial processes in SSc.”
“Aim: Our aim in this study was to examine the risk factors associated with gestational diabetes GSK1120212 concentration mellitus
(GDM) in women who did not have GDM during a previous pregnancy. Materials and methods: In this retrospective cohort study, we reviewed the charts of all pregnant women who delivered two pregnancies between January 2000 and June 2010. Group 1 consisted of patients with gestational Go 6983 mw diabetes and Group 2 served as the control. Results: There were 743 women who underwent GDM screening by means of the 50-g glucose challenge test (GCT). Thirty-eight women (5.1%) were excluded because of a previous history of GDM. The recurrence of GDM was 42.1% in this group (16 of the 38). The remaining 705 patients were divided into the GDM group (n = 38) and the control group (n = 667). Undergoing a 50-g GCT during the previous pregnancy (p = 0.000, 95% CI +0.01 to +0.002), age (p = 0.009, 95% CI +0.001 to +0.009), and weight differences between the pregnancies at the first trimester (p = 0.005, 95% CI +0.001 to
+0.007) were independent parameters related to GDM. Conclusion: The 50-g GCT during the previous pregnancy was, interestingly, increased in the GDM group. It was also an independent risk factor for women without a history of GDM.”
“Purpose of review
The purpose of this review was to give an update on the effects of physical exercise in patients with chronic inflammatory disorders with a focus on the potential anti. inflammatory effects, particularly Blasticidin S in vivo in inflammatory myopathies.
Recent findings
Until recently patients with myositis were refrained from doing physical exercise due to the fear of exacerbation of muscle inflammation. Several studies now support the beneficial clinical effects of physical exercise on physical performance, cardiorespiratory fitness and muscle strength in these patients. In this context, the observations from healthy individuals and from patients with other chronic inflammatory disorders such as rheumatoid arthritis and chronic obstructive lung disease that physical exercise or regular physical activity may lower levels of systemic inflammation markers such as C-reactive protein (CRP) and interleukin (IL) 6 is interesting.