44 Increasingly, experts also consider parts of the Rift Valley in Africa, including Darfur, Western Kenya, parts of Western Tanzania, Rwanda, Burundi, and Malawi, to pose as many risks as the traditional meningitis belt,47 but not the usual safari tourist destinations in East Africa. Recommendations may also slightly differ based on risk of exposure to PLX4032 ic50 meningococcal disease in the high-risk destination countries as described in the paragraph below. A meningococcal vaccine that covers all four serogroups (ACWY) is necessary for travelers to the African meningitis belt due to the need to protect against multiple

serogroups that cause disease in the area.41 Besides

the general destination-specific factors, we must also consider that personal exposure, living conditions, and professional and social behavior play a decisive role. Disaster relief personnel or staff for humanitarian aid (eg, in refugee camps) may be at higher risk. In the African meningitis belt, any health professional should consider not only the duration of exposure, but also whether there will be close contact Olaparib price to the local population in the activity, the accommodations, and type of public transportation. Globally, exposure in dormitories or similar accommodations may pose an increased risk of transmission, and meningococcal vaccination ought at least to be considered. Finally, host factors need to be taken into account. There is consensus that, for instance, persons with splenectomy and some with immune or complement deficiencies should receive meningococcal vaccination regardless of travel.45,47

Lck This factor is often neglected, and thus a pretravel consultation is an opportunity for catch-up vaccination in such patients; however, HIV infection is not an indication for meningococcal vaccination, although such patients “may elect vaccination.”48 Possibly these patients may only have received a vaccine against serogroup C and may request quadrivalent protection. Some health care professionals will also consider that children are at higher risk of exposure and/or that senior travelers may be immunosenescent and thus at higher risk of serious illness. As with many other immunization programs in the general population, the goal of vaccinating travelers is to both protect the individual from meningococcal disease and protect society from its spread. In view of the large variety of geographical distribution worldwide, broad coverage against all vaccine-preventable serogroups is warranted and therefore multivalent meningococcal vaccines are to be preferred over monovalent vaccines for travelers.