Evidence of the transboundary and straddling nature of some important stocks may be drawn from the geographical occurrence pattern in Protein Tyrosine Kinase inhibitor late spring and early summer, e.g. for the European hake (Merluccius merluccius) and Norway lobster (Nephrops norvegicus), which are high-value stocks targeted by the Adriatic demersal fishery. The shared character of Adriatic fishery resources makes it necessary to take in full consideration

the cooperation among states as an essential and unavoidable requirement to pursue a responsible exploitation of such resources. Considering that six countries fish in the same basin, caution needs to be exerted when assessing trends in fisheries landing. Underestimation of landed quantities is a common problem that affects available statistics to an often unknown extent. Therefore

the application of a system based on TFCs should carefully take into account all these factors. With regard to the Maximum Sustainable Yield (MSY) concept, partners believe that this index does not seem appropriate and exhaustive for the development of a sustainable fisheries management model in the Mediterranean. All partners see the MSY concept as too theoretical, and not applicable to resources which are highly interrelated and variable over time. The current determination of stock status is based on scientific assessments which do not take into account all Cyclin-dependent kinase 3 factors that have an influence on resource fluctuations (climate change impacts, maritime pollution, natural predation, recruitment variation). The MSY definition DNA Damage inhibitor is relatively easier for single or monospecific stocks, but it is very difficult in case of mixed species catches, as it is the case for Mediterranean

fisheries. Indeed, in the Mediterranean the MSY should be determined for groups of species (mixed-species MSY) according to fishing systems, seasons and areas, also considering that MSY for mixed species should have a margin of flexibility. But it is difficult to develop a method to calculate the MSY for multispecies fisheries, since there are not enough biological and life history data to determine the MSY for most Mediterranean species. There have been many objections to the EC proposal of calibrating multispecies MSY on the most threatened species, since this would cause an unnecessary ban on species with stocks in good status. Calculations could be based on the mortality rate for each target species, but this type of data may not be available. For instance, in the Adriatic Sea the state of certain populations is determined by recruitment rather than by fishing mortality, since most species have a short life cycle. In GSA 8, for example, it seems that the state of spiny lobster population does also fluctuate according to recruitment, a complex process governed by a 5-month pelagic larval phase.