Dynamic changes in ionic conductance states also contribute to the nonlinearity (Borg-Graham et al., 1998). In contrast, transmembrane currents create extracellular current sinks/sources, and these are directly related to the extracellular potential by Poisson’s equation, as incorporated into the CSD method (Freeman and Stone, 1969 and Mitzdorf, 1985). In typical (densely

packed) cases, the relative strength and symmetry of activation Galunisertib cost in two adjacent generator substrates determines which is better represented over the surrounding volume of tissue (e.g., Givre et al., 1995 and Tenke et al., 1993). The results concerning the spread of band-limited LFP signals were unexpected, given the relatively lower amplitude of higher frequency signals, and weaker coherence of higher frequency bands

INCB024360 between loci (e.g., Maier et al., 2010). However, contrary to general belief that high-frequency bands simply do not spread as far as lower frequency signals, our data indicate that band-limited signals over a wide frequency range spread as far as the full-band signals. These results seem at odds with the idea that long range volume conduction itself is limited to lower frequencies, but so does the fact that high-frequency signals can be detected in event-related potentials at epidural brain surface (Edwards et al., 2005 and Mukamel et al., 2005) and scalp (Schneider et al., 2011). It is worth noting that expressions given for the relationship between CSD and LFP have no dependence on frequency components of signals. Accordingly, all frequency bands in a signal should be volume-conducted equally. Several considerations may help reconcile the “preferential” and “egalitarian” views on volume conduction. First, in keeping with the universally observed “1/f” power distribution, local generation of LFPs as indexed by CSD analysis yields weaker strength at higher frequency cAMP bands (Lakatos et al., 2005 and Lakatos et al., 2007). We can speculate that although

generally weak, high-frequency band signals spread as far as stronger low frequency band signals, with attenuation over distance, lower frequency signals are more reliably detected at longer distances from the generator site. Additionally, a given small temporal variation in signals affects coherence more dramatically in high than in low frequency signals. That would account for the observation that better coherence seen for lower frequency bands over distance (Leopold et al., 2003 and Maier et al., 2010). Volume conduction (Mitzdorf, 1985, Mitzdorf, 1986, Nunez et al., 1991 and Schroeder et al., 1995) provides the likely explanation for manifestation of LFPs outside of the activated substrate as observed here and earlier (e.g., Arezzo et al., 1975, Legatt et al., 1986 and Schroeder et al., 1992), and indeed, for the manifestations of EEG and ERPs at the scalp (Nunez et al., 1991 and Vaughan and Arezzo, 1988).