Our study revealed that women and men suffering from colorectal cancer scored differently
across many aspects of quality of life, but with the exception of diarrhea, these differences were also found in the general population, i.e. they indicated no gender-specific reaction to disease.”
“Objectives: While anatomical and physiological changes in the spleen are reported in systemic lupus erythematosus (SLE), a complex autoimmune disease that can affect most organ systems, calcifications have not been described as a characteristic feature. We report 4 lupus patients with extensive splenic calcifications with no apparent cause except VX-680 cost for their primary disease. The relevant literature on calcifications of the spleen in SLE is also reviewed.
Methods: Four lupus patients with extensive splenic calcifications are described, identified by radiologists at 2 large urban academic centers. In addition, the relevant literature Citarinostat in vivo was reviewed (PubMed search 1947 through
May 2010) using the following terms: “”lupus,”" “”spleen,”" and “”calcified,”" “”calcification,”" “”calcifications,”" or “”microcalcifications.”" English-language case reports and series were selected.
Results: Four lupus patients were found to have a unique pattern of splenic calcifications. The age range was 36 to 73 years. Two of the patients were women, and 1 of these had SLE and limited systemic sclerosis. On reviewing the literature, 6 additional cases of lupus and splenic calcifications were found, 1 of which had pathologic assessment of the spleen on autopsy. The incidence of infection was apparently not increased in affected patients.
Conclusions: A unique pattern of calcifications of the spleen may be found in lupus patients, which can suggest the diagnosis of the underlying connective tissue disease. Whether splenic calcification can predispose to hyposplenism remains selleckchem to be determined. While the exact significance of diffuse splenic calcification
is still unknown, this unique radiologic finding may be a result of the disease process itself. (C) 2011 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 41:187-193″
“BackgroundHematopoietic stem cell transplant (HSCT) recipients have increased morbidity from respiratory viral infections. Pandemic influenza A – A(H1N1)/pdm09 – in 2009-2010 was associated with increased severity of illness in patients with underlying co-morbidities including HSCT, but the factors that contribute to severe disease in HSCT patients are not well characterized.
MethodsWe conducted a multicenter review of microbiologically proven influenza A(H1N1)pdm09 in the HSCT population between April 2009 and April 2010 to determine factors that are associated with severe disease.
ResultsWe identified 37 adult patients (26 allogeneic and 11 autologous HSCT recipients). Median time from transplant to diagnosis was 411days (range 4days-14.9years).