The present study evaluated the activity of naphtho-quinones and heterocyclic derivatives obtained from lapachol against Mycobacterium kansasii, M. tnarinum, and M. abscessus, through the REMA method. It was observed that lapachol was inactive against the three mycobateria species, while beta-lapachone and nor-beta-lapachone showed activity only against M. marinum. The most active substances for M. kansasii were the derivates 2, 3,7, and 11, in which compound 2 (CMI = 0.96 mu M) was the most active. For M. marinum, 2, 11, and 14 were the most active, while against M. abcessus the compound 3 was the only active. The results
showed a wide and diversified resistance spectrum among the species studied, which could be related to the molecular structure https://www.selleckchem.com/products/Adrucil(Fluorouracil).html and position of the substituting groups, indicating the potentiality of these molecules www.selleckchem.com/products/semaxanib-su5416.html as antimicrobial prototypes.”
“Aims
To investigate the frequency, the prognostic effect on functional status and the urodynamic patterns of post-stroke urinary incontinence (UI) in a sample of in-patients affected by ischemic stroke.
Methods
One hundred six patients
with recent ischemic stroke admitted to a neurorehabilitation unit were enrolled. Stroke localization was made according to the Oxfordshire Community Stroke Project (OCSP) stroke subtypes and assessment of stroke severity using the National Institute of Health Stroke Scale (NIHSS). The presence of UI was associated with functional status, measured with Barthel Index and Functional Independence Measure (FIM). At admission, urodynamic studies were performed on all the patients and repeated in C188-9 63 patients after 30 days.
Results
Eighty-four patients (79%) were incontinent. Incontinence was associated with age (P < 0.05) and functional disability (P = 0.01), but not with sex, side of stroke, or time from stroke to entry in the study. Urodynamic studies, performed on all 106 patients at admission, showed normal studies in 15%, detrusor overactivity (DO) in
56%, detrusor overactivity with impaired contractility (DOIC) in 14%, and detrusor underactivity (DU) in 15%. After 1 month urodynamic studies, repeated on 63 patients, showed normal studies in 30%, DO in 48%, DOIC in 6%, and DU in 16%.
Conclusions
Incontinent patients showed a worse functional outcome compared to continent patients. Post-stroke incontinence may be associated with different urodynamic patterns, each of which may necessitate different treatment strategies. Urodynamic findings in patients with ischemic stroke vary depending upon timing of the study. Neurourol. Urodynam. 33:420-425, 2014. (c) 2013 Wiley Periodicals, Inc.”
“The plasma pharmacokinetics, tissue distribution, excretion, and metabolism of gambogenic acid (GNA), potential antitumor candidate, were investigated in rats.