History of multiple pneumococcal infections during the study period ranged from 30% to 40% for all infection types. One-third of patients with both invasive and non-invasive pneumococcal pneumonia had a pneumonia ICD-9 diagnosis in the year prior to the positive pneumococcal culture. Overall, 11.9% of patients had an ICD-9 diagnosis for a Streptococcal infection (from any Streptococcus

species, including S. pneumoniae) in the previous year. Among inpatients click here with serious infections, 40.2% had chronic respiratory disease, 16.2% had diabetes, 16.2% had cancer, and 14.6% had heart failure. Approximately 12% of patients used tobacco, and the highest percentage of tobacco use was among those with non-invasive pneumonia (14.0%). Overall inpatient mortality and 30-day mortality rates were 13.6% and 17.9%, respectively. The highest mortality was

among those with bacteremic pneumonia (inpatient mortality 29.1%; 30-day mortality 28.8%) and the lowest was among those with non-invasive pneumonia (inpatient mortality 9.5%; 30-day mortality 14.2%). Prevalence of risk SN-38 factors for S. pneumoniae among inpatients with serious pneumococcal infections is presented for each year of the eFT-508 chemical structure study period in Table 3. In 2011, chronic respiratory disease (50.9%) and diabetes (22.6%) were the most common conditions in our population, while immunodeficiency disorders (0.2%) and HIV (1.8%) were the least common risk factors. The modeled annual percent change increased significantly for 3-mercaptopyruvate sulfurtransferase all risk factors assessed, except HIV and immunity disorders where the increase was non-significant. Chronic respiratory disease, diabetes, and renal failure increased by 1.9%, 1.3%, and 1.0% per year, respectively. Table 3

Annual prevalence of risk factors for Streptococcus pneumoniae in hospitalized patients with serious pneumococcal infections Year Heart failure (%) Chronic respiratory (%) Diabetes (%) Liver disease (%) HIV (%) Renal failure or dialysis (%) Immunity disorder (%) Cancer (%) 2002 11.1 33.1 11.3 4.6 1.2 5.6 0.0 13.0 2003 14.4 34.2 12.0 5.4 1.3 6.4 0.3 14.9 2004 12.2 35.7 12.5 4.0 1.4 5.1 0.0 15.9 2005 14.0 36.2 13.8 5.2 1.6 6.9 0.1 14.5 2006 14.1 35.4 14.3 5.9 1.7 8.6 0.4 16.3 2007 13.4 38.2 15.5 5.6 1.5 9.0 0.3 17.5 2008 13.9 41.6 18.5 7.2 3.1 11.1 0.1 16.3 2009 16.2 44.6 16.6 6.8 1.6 12.3 0.3 17.4 2010 16.7 47.6 21.9 7.7 1.7 13.5 0.2 16.9 2011 18.6 50.9 22.6 7.4 1.8 13.8 0.2 18.9 Annualized change in prevalence (%) 0.6 1.9 1.3 0.4 0.1 1.0 0.0 0.5 P value 0.002 <0.001 <0.001 <0.001 0.186 <0.001 0.427 <0.