[22]. Briefly, the heights of each vertebra (i.e., anterior (Ha), middle (Hm), and posterior (Hp)) were measured by placement of six points using a

cursor R428 manufacturer and backlit digitizing board. Vertebral morphometric fractures were defined using ratios of vertebral height: the Ha/Hp (wedge) ratio, the Hm/Hp ratio, and the ratio of posterior heights of adjacent vertebrae Hpi/Hp i + 1 and Hpi/Hp i − 1 (crush). A vertebral body is considered fractured when at least one of its ratios falls below 3 SDs from normative mean values. Statistical analyses The baseline characteristics of Southern Chinese postmenopausal women who had a vertebral fracture were compared with women who did not have a vertebral fracture using t tests for continuous variables and χ2 tests for categorical variables. Logistic regression models

were applied to determine the odds ratios (OR) of vertebral fracture and the 95% CI for each SD decrease in BMD, bone mineral Adriamycin concentration content (BMC), and bone mineral apparent density (BMAD). The relationship between BMD and prevalent vertebral fracture was determined using different models with adjustment for age alone, age and body weight, and a multivariable model of risk factors. Clinical risk factors were included in the multivariable model if they were associated with vertebral fractures (p ≤ 0.1). In the PI3K Inhibitor Library multivariable model, we adjusted for age (≥65 years), body mass index (BMI < 19 kg/m2), menarche age (>14 years), years since menopause (>5 years), current smoker or drinker, daily calcium intake (<400 mg/day),

history of fracture (excluding clinical spine fracture), and fall in the last 12 months. To compare the discriminative value of various measurements, we analyzed the areas under receiver operating characteristic (ROC) curves using the C statistics. Finally, the prevalence of vertebral fractures by age and number of risk factors were determined. ROC curve analysis was conducted using MedCalc package version 9.3 (MedCalc, Mariakerke, Belgium). All statistical Tolmetin analyses were performed using SPSS for Windows version 15.0 statistical software (SPSS, Chicago, IL, USA). Results Two hundred and ninety nine (22%) subjects were found to have prevalent vertebral fractures. Table 1 summarizes the baseline characteristics of the studied subjects. Compared with women who did not have a prevalent vertebral fracture, women with prevalent vertebral fractures were older, had a later menarche age, had longer time since menopause, and had a higher prevalence of smokers and alcohol drinkers. Furthermore, these women were more likely to fall during the previous 12 months, to fracture after age of 45 years, to report clinical spine fracture, and to have BMD T-score ≤−2.5 at anyone skeletal site.