Patients’ outcomes were reviewed for 2 years from the admission of acute coronary syndrome. Primary outcomes of the study included re-hospitalization for acute coronary syndrome and all- cause mortality. Results: Thienopyridines users experienced significantly more re-hospitalization for acute coronary syndrome than aspirin users (26.64% vs. 17.48%, P < 0.001), whereas adjusted hazard INCB024360 ratio [HR] was 1.56 (95% confidence interval [CI]: 1.30 to 1.88)
and all cause of mortality adjusted HR was 1.15 (95% CI: 0.99 to 1.34). Conclusion: In this retrospective analysis, aspirin treatment appeared more effective than thienopyridines for secondary prevention of acute coronary syndrome and showed a non-significant trend towards lower all-cause mortality. LIN CHIH-CHING1,2, YANG WU-CHANG1,2 1Taipei Veterans General Hospital; 2National Yang Ming University Introduction: Elevated
plasma asymmetric dimethylarginine (ADMA) has been reported to be associated with restenosis after percutaneous transluminal angioplasty (PTA) of AVF in hemodialysis (HD) patients. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is the major enzyme eliminating ADMA, but the effect of genetic variations in DDAH1 on the outcome of vascular access after PTA in HD patients remained unknown. Methods: We assessed the association between polymorphisms in DDAH1 and vascular access outcome in 473 maintenance HD patients, who were prospectively followed up for one learn more year after PTA for vascular access dysfunction. Eleven single nucleotide polymorphisms (SNPs) in endothelial function related genes were analyzed and plasma ADMA levels were determined at baseline. Results: After adjustment of demographic,
access, and risk factors, individuals with high baseline plasma ADMA (>0.9 μM) levels had higher rates of re-intervention at 6 months after PTA (74% vs. 53%, p = 0.05). DDAH1 rs233112 was significantly associated with increased levels of plasma ADMA levels. Compared with individuals with rs233112 AA genotypes, individuals with rs233112 GA or GG genotypes had higher risks for re-intervention (58% vs. 45%, p = 0.003) after PTA at 6 months. Carnitine palmitoyltransferase II In the same multivariate- adjusted model, the clinical factors predicting higher risk of re-intervention at 6 months include current smoker, graft access, and rs233112 GG+GA genotypes of DDAH1 gene (HR 2.302, 95% CI 1.557–3.407). Conclusion: Our study demonstrate that rs233112 GG+GA genotypes of DDAH1 gene predict early and frequent restenosis of vascular accesses after PTA in HD patients. SEONG LIM PAIK, CHUNG JENG YA, YING WU MING Tungs’ Taichung Metroharbour Hospital Introduction: Chronic inflammation in dialysis patients may cause malnutrition and progressive atherosclerotic CVD and available data suggest that pro-inflammatory cytokines play a central role.