05). Conclusion: Conclusions: The results suggest that oxymatrine, cisplatin and oxaliplatin would have inhibiting effect on cell proliferation in human hepatocelluar carcinoma cell line Bel-7404, which would be strengthened and attain synergism when oxymatrine worked combinedly with cisplatin or oxaliplatin and oxaliplatin
was superior to cisplatin whether it worked separately or combinedly. Its mechanism may be related to the blocking of cell cycle at G0/G1 phase and inducing cell apoptosis. Key Word(s): 1. oxymatrine; 2. HCC cell Bel-7404; 3. cisplatin; 4. oxaliplatin; Presenting Author: WUHUA GUO Additional Authors: FC WANG, ZY XIE, JX ZHANG Corresponding Author: WUHUA GUO Affiliations: the second affiliated hospital of nanchang university Objective: TACE oriented comprehensive therapy is a popular choice for treatment of hepatocelluar carcinoma, especially the unresectable primary liver cancer. In this research, CT-guided learn more microwave ablation was applied for patients with incompletely treated hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). The article is to evaluate the efficacy and safety for this therapy. Methods: 37 patients with single or multi nodular HCC were treated with TACE combined with microwave ablation. All patients were firstly treated with TACE 1 or 2 times. Then CT-guided microwave ablations
were performed to treat the masses incompletely treated according to CT/MRI. All patients were evaluated for complete tumor ablation rate, local recurrence-free rate, overall survival rate, and complications. Results: The times of procedure Akt inhibitor drugs were 137 and 82 for TACE and microwave ablation respectively in all 37 cases of HCC. The complete tumor ablation rate was 65.3% (32/49). One-, 2-, 3-, and 4-year overall survival
rates were 91.9% (34/37), 70.0% (26/37), 16.2% (6/37), and 5.4% (2/37), respectively. Complications were observed in 4 patients, one with descending duodenum perforation (Tumor infiltrated duodenal, abscess formation within the tumor 15 days after ablation. The patient P-type ATPase didn’t have the clinical manifestations of acute peritonitis.), and the other with right pleural effusion. Conclusion: The strategy of TACE combined with microwave ablation could be effective and safe for the treatment of HCC. CT-guided microwave ablations would be an ideal companion for TACE especially incompletely treated masses. Key Word(s): 1. HCC; 2. Ablatin; 3. TACE; Presenting Author: XIULAN PENG Corresponding Author: XIULAN PENG Affiliations: Renmin Hospital of Wuhan University Objective: Purpose Hepatocellular carcinoma (HCC) is one of the most common malignant tumor. The molecular mechanism of HCC is poorly understood. Our previous study have shown that upregulation of Ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) could inhibit malignant biological characteristics of HCC, We aimed to confirm the function of EBP50 in human hepatocellular carcinoma.