The data generated in the current study were compared to the literature.”
“The objective of the present study was to evaluate a novel film forming biomaterial for its potential application in the preparation of unilaminate transdermal adhesive matrix systems. The biomaterial, Damar Batu (DB), was tried alone and in combination with Eudragit RL100 JNJ-64619178 cell line as a matrixing agent in the preparation of transdermal patches. Developed transdermal

patches of Diltiazem hydrochloride (DH) were evaluated for thickness uniformity, weight uniformity, folding endurance and drug content. USP dissolution apparatus V was used for in vitro drug release studies. Modified Franz diffusion cell used for permeation study using excised human cadaver skin. Total 6 formulations were developed and on the basis of in vitro drug release and in vitro skin permeation profile F5 composed of DB:Eudragit RL100 (60:40) and carrying 20 % w/w DH was selected as an optimized formulation for in vivo study. The in vivo study results showed that F5 achieved the Cmax of about 269.76 +/- 1.52 ng/mL in 6 h and sustained the release of the drug till 24 h. The skin irritation study results proved selleckchem that the

novel biomaterial is non-sensitizing and non-irritating. Drug-polymer interaction study carried out to check the compatibility of drug and polymer showed the intactness of the drug in the formulation proving the compatibility of the polymer. It can be proposed from the outcome of the present study that by applying suitable adhesive layer and backing membrane, DB:Eudragit

RL100 (60:40) transdermal patches can be of potential therapeutic use.”
“Poly(dimethylsiloxane)(PDMS)-based triblock copolymers were successfully synthesized GSI-IX molecular weight via atom transfer radical polymerization (ATRP) initiated with bis (bromoalkyl)-terminated PDMS macroinitiator (Br-PDMS-Br). First, Br-PDMS-Br was prepared by reaction between the bis(hydroxyalkyl)-terminated PDMS and 2-bromo-2-methylpropionyl bromide. PSt-b-PDMS-b-PSt, PMMA-b-PDMS-b-PMMA and PMA-b-PDMS-b-PMA triblock copolymers were then synthesized via ATRP of styrene (St), methyl methacrylate (MMA) and methyl acrylate (MA), respectively, in the presence of Br-PDMS-Br as a macroinitiator and CuCl/PMDETA as a catalyst system at 80 degrees C. Triblock copolymers were characterized by FTIR, H-1-NMR and GPC techniques. GPC results showed linear dependence of the number-average molecular weight on the conversion as well as the narrow polydispersity indicies (PDI < 1.57) for the synthesized triblock copolymers which was lower than that of Br-PDMS-Br macroinitiator (PDI = 1.90), indicating the living/controlled characteristic of the reaction. Also, there was a very good agreement between the number-average molecular weight calculated from (HNMR)-H-1 spectra and that calculated theoretically.